Research and Development Laboratory

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bruce

Bruce Budowle, Professor

Dr. Bruce Budowle received a Ph.D. in Genetics in 1979 from Virginia Polytechnic Institute and State University. From 1979-1982, Dr. Budowle was a postdoctoral fellow at the University of Alabama at Birmingham. Working under a National Cancer Institute fellowship, he carried out research predominately on genetic risk factors for diseases such as insulin dependent diabetes mellitus, melanoma, and acute lymphocytic leukemia.

From 1983-2009, Dr. Budowle worked at the FBI Laboratory Division to carry out research, development, and validation of methods for forensic biological analyses. Dr. Budowle has contributed to the fundamental sciences as they apply to forensics in analytical development, population genetics, statistical interpretation of evidence, and in quality assurance. Some of his technical efforts have been: 1) development of analytical assays for typing a myriad of protein genetic marker systems, 2) designing electrophoretic instrumentation, 3) developing molecular biology analytical systems to include RFLP typing of VNTR loci and PCR-based SNP assays, VNTR and STR assays, and direct sequencing methods for mitochondrial DNA, and 4) new technologies; and 5) designing image analysis systems. Dr. Budowle has worked on laying some of the foundations for the current statistical analyses in forensic biology and defining the parameters of relevant population groups. He has published more than 490 articles, made more than 580 presentations (many of which were as an invited speaker at national and international meetings), and testified in well over 250 criminal cases in the areas of molecular biology, population genetics, statistics, quality assurance, and forensic biology. In addition, he has authored or co-authored books on molecular biology techniques, electrophoresis, protein detection, and microbial forensics. Dr. Budowle has been directly involved in developing quality assurance (QA) standards for the forensic DNA field. He has been a chair and member of the Scientific Working Group on DNA Methods, Chair of the DNA Commission of the International Society of Forensic Genetics, and a member of the DNA Advisory Board. He was one of the original architects of the CODIS National DNA database, which maintains DNA profiles from convicted felons, from evidence in unsolved cases, and from missing persons.

Dr. Budowle’s efforts over the past decade also have focused on counter terrorism specifically efforts involving microbial forensics and bioterrorism. Dr. Budowle was involved directly in the scientific aspects of the anthrax letters investigation and has been one of the architects of the field of microbial forensics. He has been the chair of the Scientific Working Group on Microbial Genetics and Forensics (hosted by the FBI), whose mission was to set QA guidelines, develop criteria for biologic and user databases, set criteria for a National Repository, and develop forensic genomic applications. He currently serves on other government working groups related to microbial forensics. He also has served on the Steering Committees or been a co-organizer for the Colloquia on Microbial Forensics sponsored by American Society of Microbiology, Microbial Forensics Meetings, hosted by DHS, held at The Banbury Center in the Cold Spring Harbor Laboratory, and a meeting on Microbial Evolution and Cutting Edge Tools for Outbreak Investigations, hosted by the Centers for Disease Control and Prevention. He has published a number of articles (see below) on microbial forensics on topics such as attribution, quality assurance, population genetics, next generation sequencing technology, and sample collection. His current efforts at UNTHSC continue to focus on the areas of human forensic identification, microbial forensics, and emerging infectious disease.


Antti
Antti Sajantila, MD, PhD, professor

Antti Sajantila is spending his sabbatical year 2013 /2014 as a visiting professor in the Budowle lab, funded by the Finnish Foundations’ Professor Pool (Paulo Foundation) (http://www.profefessoripooli.fi).

Antti Sajantila received his PhD in 1992 under Professor Leena Peltonen, and MD in 1993 from the University of Helsinki, Finland. He was in charge of the forensic DNA testing in Finland in the former National Public Health Institute, until he left for the post-doc studies to Munich, Germany under Professor Svante Paabo. He returned to Finland in 1996 to lead the newly founded DNA laboratory in the Department of Forensic Medicine at the University of Helsinki, gained an associate professorship in forensic genetics in 1998, and a degree of specialist in forensic medicine (forensic pathology) in 1999. Antti Sajantila held the position of a full Professor in forensic medicine at the University of Oulu in Finland in 2002 and returned in 2003 to the Department of Forensic Medicine at University of Helsinki as a full professor in genetic forensic medicine. Antti Sajantila has been a short-term invited professor in the Department of Biology, University of Ferrara, Italy (2000) and in the Department of Anthropology, University of Florence, Italy (2001). Currently he is the director of the Department of Forensic Medicine in Helsinki (http://www.hjelt.helsinki.fi).

Antti Sajantila has over 160 scientific publications including original articles, book chapters, editorials and popular science. His scientific interests are in population genetics and human history, forensic genetics, pharmacogenetics and medico-legal cause of death investigation. Antti Sajantila serves in the editorial boards of International Journal of Legal Medicine; Forensic Science, Medicine and Pathology; Forensic Science International Genetics; and he is a co-Editor-in-Chief of Investigative Genetics (www.investigativegenetics.com) together with professors Bruce Budowle and Manfred Kayser.

Besides scientific work Antti Sajantila is a practical generalist in forensic medicine. He is a forensic pathologist in the Finnish DVI Team, and a vice-chair of the Interpol’s Forensic Pathologist Working Group. Antti Sajantila is a member of the Finnish Forensic Expert Team, and he has participated in missions e.g. in Kosovo, Peru, and Libya. He is also a member of the International Forensic Expert Group, which promotes the Istanbul protocol in investigations of alleged torture and other cruel, inhuman or degrading treatment or punishment (http://www.irct.org/our-support/medical-and-psychological-case-support/forensic-expert-group.aspx).

Antti Sajantila has been awarded with the prize of the International Society of Forensic Genetics (ISFG) (1997), Finnish Medical Foundation’s 40th Anniversary Science Prize (2000) and an honorary medal from the Finnish Association for Cherishing the Memory of the Dead of the War (2010) for his work in identification of the Finnish M.I.As in the World War II. For his work for the Truth and Reconciliation Commission in Peru, he was promoted to be professor honoraria causae in the Pontificial University of Lima, Peru. Besides professional activities Antti Sajantila is interested in basketball, cinema and fine arts. He consults writers and film makers on regular basis concerning forensic issues in the society and he has appeared as an actor in movies, such as “Priest of Evil” (2010) and “Hush” (2012) (http://www.imdb.com/name/nm4119498/?ref_=fn_al_nm_1). Antti Sajantila collects contemporary art and owns - to the best of his knowledge - the world’s largest collection of artwork by Tatjana Bergelt (www.tatjanabergelt.com).


Dr. Liu
Chao Liu, Visiting Scientist

Dr. Liu is the chief scientist in Guangzhou Institute of Forensic Science, China. He engaged in forensic genetics research twenty-five years ago. His research aspects include: development of new method to extract and purify degraded DNA samples, STR typing of low copy number (LCN) DNA samples, polymorphisms of Y-chromosome DNA typing, application of DNA database in forensic science etc. He is also an expert in criminal scene investigations. Dr. Liu has been appointed as the director of Forensic Science Institute of Guangzhou, professor of Southern Medical University (Guangzhou, China) and Sun Yat-sen University (Guangzhou, China), the director of Guangdong Province Key Laboratory of Forensic Genetics. He joined Dr. Budowle’s Lab as visiting scientist on October 2013. He loves dogs and Mexican food, and enjoys his time in the US.


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Jonathan King, Laboratory Manager

Jonathan King is originally from North Carolina but has lived in Texas long enough to be considered a naturalized Texan. He received his MS from Tarleton State University in 2009 with a research focus in capturing novel polymorphic Indels from agricultural pathogens. He has been the laboratory manager for the research and development lab since March 2011. Jonathan’s current research projects include DNA repair, small amplicon markers, mitochondrial sequencing, novel DNA extraction techniques, and molecular medicine, just to name a few. When he is not working, Jonathan enjoys photography and the culinary arts.


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Bobby LaRue, Research Assistant Professor

Bobby LaRue earned his PhD at the University of North Texas in 2010. His dissertation focused on the stress experienced by metazoans in low oxygen environments and the cell signaling pathways used to ameliorate the damage caused by these conditions. In 2010 he was awarded an Intelligence Community postdoctoral fellowship. His current research interests include small amplicon markers for human and tissue identification including SNPs, small INDELs, LINEs and SINEs, and methylation patterns. His ultimate goal is to be able to improve typing of degraded and low quantity samples. When not in the lab, Bobby enjoys spending time with his family and being outside.


Jennifer Churchill
Jennifer Churchill, PostDoc

Jennifer Churchill is a Postdoctoral Research Associate from Belton, Texas. She graduated in 2009 from Texas A&M University with a Bachelor of Science in Biochemistry. Jennifer received her Ph.D. in Biomedical Sciences from the University of Texas Graduate School of Biomedical Sciences where she specialized in Human and Molecular Genetics. Her Ph.D. work focused on the use of linkage and next-generation sequencing technologies to identify novel autosomal dominant Retinitis Pigmentosa genes. Following her Ph.D. defense in December 2013, Jennifer joined Dr. Bruce Budowle’s lab as Postdoctoral Research Associate in January 2014. Her work will focus on forensic applications of massively parallel sequencing. When not in the lab, Jennifer enjoys spending time with her family and friends.


Angie_AmbersAngie Ambers, Forensic Technologist II

Although originally from Tennessee, Angie has lived in the Dallas-Fort Worth metroplex for over 15 years. She has a Master's degree in Forensic Genetics from the University of North Texas Health Science Center and another Master's in Criminology from U.T. Arlington. Her thesis research involved developing and optimizing a DNA-based multiplex screening tool for the separation of fragmented & commingled skeletal remains. Since 2005, Angie has been an adjunct instructor on the Denton campus (teaching Genetics, Heredity, and Human Anatomy & Physiology); and in 2008 she developed the curriculum for a course in Forensic Molecular Biology, in which she teaches DNA analysis/methodology to undergraduate students enrolled in the FEPAC-accredited forensic science certificate program. She was also lead DNA analyst & lab manager of UNT Denton's DNA Sequencing Core Facility for two years, and during that time had the opportunity to work on various ancient DNA projects involving archeological specimens from Greenland. Currently pursuing a Ph.D. in Molecular Biology, her research focuses on the repair of degraded DNA in skeletal remains and environmentally-damaged bloodstains. During her free time, Angie enjoys traveling, hiking, and spending time with her miniature dachshunds.


pam 2Pamela Marshall, Ph.D. Candidate

Pam Marshall has been involved in the field of forensic analysis since 2002. Upon the completion of her Master’s degree in Forensic Genetics in 2002, she worked as a Forensic Scientist III at the Maryland State Police Forensic Sciences Division from 2003-2007. While in Maryland, Pam became an expert on sexual assault kit examination and collection practices. Pam was the Sexual Assault Forensic Examiner (SAFE) Coordinator for the state, helped to promote 120-hour SAFE collection legislation, and assisted in the training of over 200 SAFE nurses. She has extensive teaching experience and has taught graduate-level coursework in the forensic disciplines of serology, DNA, and microscopy. Pam has also worked as a Forensic Biologist at the Southwestern Institute of Forensic Science, located in Dallas, Texas. She has been qualified as an expert witness in the field of serology in Maryland and Texas. She has been a member of the Mid-Atlantic Association of Forensic Scientists, an Associate Member of the International Association of Forensic Nurses, and is a current Associate Member of the American Academy of Forensic Science. She holds an additional Master’s degree from the University of North Texas Health Science Center at Fort Worth, TX, in Biochemistry and is currently a Ph.D. Candidate in Medical and Molecular Genetics, under the guidance of major professor, Dr. Bruce Budowle. Her research interests include low copy number DNA, pressure cycling technology, and PCR enhancement.


careyCarey Davis, Ph.D. Candidate

Carey Davis is a PhD student at the University of North Texas Health Science Center. She completed her B.S. in biochemistry at the University of Virginia while working in the pathology department laboratory headed by Dr. Dennis Templeton. She then continued to Virginia Commonwealth University and received her M.S. in Forensic Science while working under the direction of Dr. Tracey Dawson Cruz on low copy number analysis. Since her arrival to UNTHSC, she has worked on many projects including: low copy number techniques, Y-STR development, and STR variant analysis. Her main research focuses on molecular autopsy and employing next generation sequencing techniques to the world of forensics. In her free time, she enjoys scuba diving, traveling, and working as a volunteer firefighter.


Sarah SchmedesSarah Schmedes, Ph.D. Candidate

Sarah is a native Texan and originally from Austin, TX. She graduated in 2007 from Texas State University with a Bachelor of Science in Biochemistry and Microbiology. In 2009 she graduated with a Master of Science in Forensic Biology from SUNY Albany. While pursuing her master’s degree, Sarah completed an internship at the McMaster Ancient DNA Centre at McMaster University in Hamilton, ON under the direction of Dr. Hendrik Poinar. Sarah’s work contributed to a project focused on isolating and identifying Yersinia pestis as the causative agent from 14th-century Black Death Victims. The project resulted in a publication which was featured on the cover of Nature in October 2011. Upon completion of her master’s degree, Sarah became employed at the Institute of Applied Genetics at the University of North Texas Health Science Center (UNTHSC) in Fort Worth, TX and worked on various research projects involving human forensic DNA analysis and tick-borne disease research. In August 2011, Sarah joined the Forensic Genetics PhD program in the Department of Molecular and Medical Genetics at UNTHSC. Sarah is currently a 3rd year PhD student studying under the direction of Dr. Bruce Budowle. Sarah’s research focus is in microbial forensics and metagenomics. In her free time Sarah enjoys hiking, traveling, and playing a good board game.


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David Warshauer, Ph.D. Candidate

David Warshauer is a Ph.D. student from Lubbock, Texas. Though he was born in the United States, he spent the majority of his youth in Saudi Arabia. He holds a Bachelor of Science Degree in Biology from Lubbock Christian University, where he earned the Dean's Award for most outstanding academic performance in the College of Professional Studies.  David also holds a Master of Science Degree in Forensic & Investigative Genetics from the University of North Texas Health Science Center. He is presently performing a validation of mitochondrial DNA analysis using the PLEX-IDTM mass spectrometry instrument, as well as investigating the transfer of saliva-based DNA. At present, David's primary focus is the use of Massively Parallel Sequencing for the detection of forensic STRs and SNPs. David currently lives in Fort Worth with his wife, Cortney, and their two miniature dachshunds. 



Xiangpei ZengXiangpei Zeng, Ph.D. Student

Xiangpei Zeng is a second year PhD student in Dr. Budowle’s lab at the University of North Texas Health Science Center. He was born in China, and  received his medical degree from medical school of Sun Yat-sen University (Guangzhou, China) in Forensic Medicine. He continued to study in Sun Yat-sen University and received his Masters Degree in Forensic Genetics under the guidance of Dr. Hongyu Sun on the application of X-STRs in Chinese populations. Xiangpei moved to USA in 2011 and spent one year in the Department of Biology at University of Alabama (Tuscaloosa) as a PhD student. In August 2012, He joined the Department of Molecular and Medical Genetics at UNTHSC and continued his study in Forensic Science. His primary research focus is the application of ancestry informative markers in Forensic Genetics using massively parallel sequencing technology. He likes reading and traveling when he is free. 



Nicole NovroskiNicole Novroski, Ph.D. Student

Nicole is a first year PhD Student under the guidance of Dr. Bruce Budowle at the University of North Texas Health Science Center.  She was born and raised in Canada, and completed her Bachelors Degree in Forensic Science and Biology at the University of Toronto.  She then worked with the Royal Canadian Mounted Police in Northern Alberta before moving on to the University at Albany, SUNY to complete her Masters Degree in Forensic Molecular Biology.  Following graduation in 2011, Nicole spent some time at the NYC Office of Chief Medical Examiner Department of Forensic Biology as a Criminalist and left in 2013 to pursue her studies at UNTHSC.  Her current research focus is in pharmacogenetics using massively parallel sequencing.  When she isn't studying, Nicole enjoys running, reading, volunteering, and spending time in Canada with family and friends. 



Monika StoljarovaMonika Stoljarova, Visiting Scientist

Monika, the only Estonian in our team, is a Master’s student of Genetic Engineering at Tallinn University of Technology. She received her BSc in 2012 after defending her thesis researching genetic material of green algae species in order to establish a suitable genetic barcoding system. Shortly after came a change in her field preference and gotten inspired by her supervisor she decided to jump into forensic genetics. Therefore, she took a year off her studies to come to Texas and Dr. Budowle’s lab in October 2013 to complete a year-long internship. Although she is a helping hand in a variety of lab projects as her goal here is to learn learn and learn more, her main project is based on the use of massive parallel sequencing. When she is not qPCR'ing, she loves travelling, sports and salsa limon tacos.



Changhui LiuChanghui Liu, Visiting Scientist

Changhui has been working in Guangzhou Institute of Forensic Science in China since 2000, after he graduated from Sun Yat-sen University (Guangzhou, China) with a Bachelor Degree in Biochemistry. Changhui received his master Degree in 2005 and currently is a Ph.D. student in Southern Medical University (Guangzhou, China). He has testified many criminal cases involving forensic genetics for his job. He joined Dr. Budowle’s lab as a one-year-term visiting scientist in October 2013. His previous research focused on population genetics and SNPs application in forensic science. Now he is studying the application of INDELs as polymorphism makers in forensic science. In his free time, Changhui loves watching TV shows online and riding a bike along the Trinity Trail.



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This page last updated 28th Feb 2014